Sentence examples for binding conformation or a from inspiring English sources

Given a crystallographic binding conformation or a three dimensional computational binding hypothesis, the program identifies the global minimum conformation, the local minimum closest to the input conformation as well as four intermediate conformations between the input and the local minimum.

Experimental validation of the taxol binding conformation, or a closely related form, was provided by a series of REDOR NMR experiments on labeled paclitaxels.

Consequently, using the paclitaxel binding conformation or pharmacophore in the design phase for such significantly pruned agents would be misleading.

These observations suggest that in a specific cell line DEX, FA, or TA generate a unique ligand-GR binding conformation, a unique GR-DNA binding domain conformation, and the subsequent recruitment of distinct co-repressors or co-activators.

The second, "specific binding" conformation binds only the complementary DNA sequence with high affinity.

Therefore, this down-cis conformation of NikR corresponds to a specific binding conformation that can recognize and bind the nik operon with the measured "high affinity" or nanomolar dissociation constant (2, 4).

Obviously, accurately predicting the binding conformation of peptides will be a major obstacle due to the high number of rotatable bonds, despite some significant progress [88].

The lowest-energy binding conformations indicated an orientation that enables hydrogen bonding interactions between the sulfate groups and Lys15.

The latter is a critical drawback if molecular designs of simpler PTX structures are based on a perceived or known PTX binding conformation.

This form was converted upon stimulation into a binding conformation, which we called open-CD3.

The similar binding conformation observed in these receptors is a testament to the multiple complementary hydrogen bond donors and acceptors afforded by the U conformation.