Sentence examples for binding conformation of compounds from inspiring English sources
The binding conformation of compounds 15 and 9 forming hydrogen bonds with Tyr355 in similar manner to naproxen confirms the importance of Tyr355 and confirms the findings highlighted with indomethacin.
To summarize, the behavior of the active site in presence of different modulators suggests that the difference in binding conformation of compounds could be attributed to structural differences in either the protein subunits or the compounds, and hence could possibly be a reason for their selective functional efficacy profiles.
Substituting SRC-1 with Adnectin-1 does not alter the binding conformation of Compound-1 in the ligand binding pocket.
Docking studies of the representative compound revealed the binding conformation of these compounds and provided critical insights for the further development of PTTD analogues.
Analysis of the binding conformation of 42 in active site displayed compound 42 was stabilized by hydrogen bonding interactions with Lys822, which was different from other derivatives.
Clearly, the binding conformation of DB00631 was impacted by the co-binding peptide.
Figure 3 shows the binding conformation of orlistat (left) and vibralactone (right) in the active site.
The work is initiated to find the binding conformation of the therapeutically promising mucin epitope pentapeptides.
Visual inspection for predicted binding conformations of most potent compounds 5l and 4i (IC50 = 17.2 ± 0.44 M and IC50 = 17.6 ± 0.23 M) revealed that both compounds can adopt conformation for a better fit into the binding groove of urease.
To further explore the binding mechanisms of these new inhibitors, we determined the X-ray structures of the complexes of FABP4-9 and FABP4-10, which revealed similar binding conformations of the two compounds.
