Sentence examples for binding conformation is the from inspiring English sources
Our results therefore indicate that ArfA directly binds to the arrestin C-domain of AdcA and that the binding conformation is the GDP-loaded form.
Because the variation in the binding conformation is large, and the CDRs interact with different (but overlapping) epitopes in the peptide, a direct comparison of CDR sequences is not relevant.
The highest ranking ligands are transposed from the target to the query structure where their binding conformation is optimized using the LigDockCSA protein ligand docking program [33].
We were first interested in evaluating the performance of the predictions in a favorable scenario, that is, when the binding conformation is known from experiment.
The binding conformation is presented in Figure 2. At this stage it can be hypothesized that ibuprofen prevents interaction between Ebola virus and ECM by blocking the interaction between GP1 and EMILIN.
To be consistent in the interpretation of our docking results, only the lowest-energy binding conformation is indicated per PCB sulfate.
Additional powerful support for the taxol binding conformation was provided by the synthesis of bridged paclitaxels locked into conformations designed to mimic those of T-taxol.
Collectively, these findings demonstrate the importance of coordinated mutagenesis, structural modeling, and medicinal chemistry studies in designing drugs against an important cancer target for which appropriate drug affinity and binding conformation are mutually indispensible for competent inhibition.
The significant difference between the wide and common binding conformations is in which amino acid residues are involved in the interaction and not in how decoron curvature changes to accommodate a tightly curved small fibril.
Based on the binding and mutagenesis studies, the sugar-binding conformation is likely to resemble closely that of the bovine CRD with bound trehalose.
The calculated and re-fit 1 : 1 values, K 11 and K 11(Z / S ) respectively, for Br– on the other hand are quite similar, and seem to confirm that binding in the Z conformation is the most dominant form.
