Sentence examples for binding compromises from inspiring English sources
Phosphotyrosine recognition by the SH2 domain may also modulate kinase activity since substitution of the conserved R171 in the SH2 domain with leucine, which abrogates pTyr binding, compromises Abl kinase activity and substrate phosphorylation.
- Thus we predict that, in circumstances when importin α accumulates in the nucleus, certain transcription factors interact with importin α via their cNLS and this binding compromises or changes their transcriptional activities.
Whether the effect of the anti-SRP autoantibodies is simply to prevent the authentic binding of SRP54 and the SRP receptor, or whether their binding compromises a specific function such as GTP hydrolysis, remains to be established.
Mr. Benvenisti is similarly pessimistic, saying that in the critical "emotional aspects of the conflict," Israelis and Palestinians do not appear ready for a lasting, binding compromise.
However, recombinant aequorin emits a relatively small signal upon Ca2+ binding which compromises the measurement of Ca2+ concentrations in smaller cells at the cost of low time resolution [ 14].
Anti-PD-1 Abs were found to be FcγR independent in vivo; the presence of FcγR-binding capacity compromises their anti-tumor activity.
Interestingly, RNAi against H02I12.1, which contains a peritrophin A chitin-binding module, compromises the egg osmotic integrity during early embryogenesis [56], suggesting that this gene plays a role in eggshell chitin deposition.
This was the only form observed when lipid or ATP binding was compromised through point mutations in the respective domains.
A screen of non- BRCA1 or BRCA2 mutant familiar breast tumors identified a in-frame deletion of residue 81 glutamic acid of Rap80 that displays reduced ubiquitin binding and compromised ability to recruit A complex and BRCA1 to DSBs [ 73].
However, these methods are not suitable in cases in which ligand binding is compromised in the presence of the detergent and/or is limited by the availability of antibodies with high specificity.
Most published evidence therefore supports the view that the T158M mutation compromises binding between MeCP2 and methylated DNA.
