Sentence examples for binding compounds that are from inspiring English sources

Finally, we discuss metal binding compounds that are designed to cross the blood brain barrier and restore metal homeostasis as potential Alzheimer's disease therapeutics.

Tramiprosate (also referred to as homotaurine and 3-amino-1-propanesulfonic acid, or 3APS) is an Aβ-binding compound that was developed using in vitro and in vivo model systems [ 9] that left some uncertainty regarding the brain concentration necessary for a pharmacodynamic effect in human AD.

Further, we examined the PPARγ binding of semivolatile organic compounds that are structurally similar to known PPARγ agonists, such as organotins and halogenated bisphenols.

Compounds that are bound at the DNA surface (groove binding or electrostatic binding) are more accessible and emission from these molecules can be quenched more efficiently.

The binding phenomena analyzed from isothermal titration calorimetry showed exothermic binding for both compounds that was favoured by negative enthalpy and positive entropy changes typical of intercalative binding.

When a rather large number of molecules had been described that act through the same target (e.g., for the capsid binding agents), we selected those compounds that were in the most advanced state of development and preferably had been studied in a clinical setting.

This study further validated the methodology the authors employed to identify MREs with high affinity and low cross-binding activities on structurally similar compounds and compounds that were likely to coexist in the environment.

A database was compiled with compounds that were tested in in vitro bioassays measuring the TTR-binding potency (Table  S1).

In this review we highlight the biomarker PS and various PS-binding compounds that have been employed to target PS for diagnostic purposes.

Examples of five estrogen receptor binding compounds that could be entered in a profile query.

Additional SOL program calculations for molecules from the training and testing sets show that the energy of −7 kcal/mol sifts out all inactive compounds; that is, SOL binding energies of all inactive ligands and ones of several active inhibitors lie above this boundary.