Tubulin-binding compounds such as vincristine, colchicine and paclitaxel, inhibit the progress of cell mitosis through the inhibition of the dynamic formation of mitotic spindle during G2/M phase.
We propose that treatment with copper-binding compounds such as CQ and PDTC will result in these compounds behaving as tumor 'sensors' using copper as a selection criterion.
Haem-binding compounds such as ODQ 1 and its 8-bromo-analogue NS2028, show activity against other haem containing proteins as such as haemoglobin, albeit at high concentrations.
6-CN-PiB did not label dystrophic neurites, indicating that plaque-associated neuritic elements do not likely contribute to overall PiB signal, despite the robust labelling of these structures with other amyloid-binding compounds such as X-34.
NQR is highly induced by Ah receptor-binding compounds such as coal tar constituents and 3-MC and also by butylated hydroxytoluene, which does not bind to the Ah receptor (Merk et al. 1991).
On one hand, several key studies have demonstrated that the use of Zn2+-binding compounds such as clioquinol or PBT2 restore Zn2+ homeostasis, greatly reduces A β pathology and protects against cognitive decline in transgenic AD models.
In the case of combinations of tubulin-binding compounds, such as ZD6126 and PTX, VDA-induced necrosis and proliferation index can been used as biological readouts to optimise scheduling of treatments.
Positron emission tomography (PET) imaging of amyloid deposits (Klunk et al., 2004; Verhoeff et al., 2004; Small et al., 2006) employs blood brain barrier penetrant amyloid-binding compounds such as the thioflavin-T derivative Pittsburgh Compound-B (PiB) (Klunk et al., 2001, 2004; Mathis et al., 2002, 2004, 2005).
Blocking the interaction between CypA and NS5A by a cyclophilin-binding compound such as DEB025, results therefore in inhibition of HCV replication.
