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Mbp1 is the DNA binding component of MBF complex, which binds to the promoters of DNA synthesis genes and regulates gene expression during G1/S transition [ 11, 16- 18].
These data suggested specific binding component of [11C]HMS011 in the brain.
The production of cement (key binding component of concrete) is costly, consumes high energy, depletes natural resources and emits huge amounts of greenhouse gases (1 ton of cement production emits ∼1 ton of CO2).
In addition to the specific binding of [18F]NS14490 in the brain, our data prove an α7 nAChR specific binding component of [18F]NS14490 in the large arteries supplying the brain.
The distribution of [11C]GSK1034702 was homogenous throughout the brain, with regional VT values of similar magnitude (see Table 1 and associated K1 values are reported in Additional file 2: Table S1A), suggesting that any specific binding component of [11C]GSK1034702 is small compared to the 'free and non-specific' binding component.
We did not see conclusive evidence for a change in regional VT values for GSK103702 following a pharmacological dose that was statistically significant, suggesting that any specific binding component of [11C]GSK1034702 is negligible compared to the free and non-specific components.
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The CNT sorption may alter the composition of the ecotoxicological test media by binding components of the media.
We show that adding background knowledge on important binding components of ligands to both, the MCS similarity and the ECFP similarity, changes the virtual screening ranking in such a way that the top structures have improved docking scores, related structures are ranked at better positions and clearly improved enrichment factor values are obtained.
Dbi is an insulin-regulated transport molecule with numerous functions and protein interactions ranging from regulation of lipid metabolism [38] to binding components of inhibitory neurotransmission machinery [39].
The oppD gene of M. tuberculosis, encoding the two ATP binding components of the transporter, was disrupted by deletion and insertion of a kanamycin resistance cassette and confirmed by Southern hybridization (Fig. 4A).
The ATP binding components of the ABC transporters revealed varying splits and radiations, indicating duplications to serve different functions in the genome (fig. 8 A).
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