Sentence examples for binding cleft while the from inspiring English sources

The T cell bears a surface receptor (T cell receptor, or TCR) that binds to the T cell epitope's amino acid side chains facing upwards, out of the MHC binding cleft, while the MHC binds to the T cell epitope's amino acid side chains facing into "pockets" located on the sides and bottom of the binding cleft.

This prevents the antigen from exiting the binding cleft, while also serving as a signaling trigger to T-cells resulting in an immune system response.

Furthermore, extensive comparisons among different family 18 chitinases demonstrated that the TIM domains + CID can bind long-chain substrates by providing a deep substrate-binding cleft, while this may not be the case for the enzymes with the TIM domain alone.

Residues 385 and 388 face away from the T strand binding cleft, while 394 faces into the T strand binding cleft and 393 is in an intermediate position.

Domain I (residue 8 101) and II (residue 102 184) form a substrate-binding cleft, while domain III (residue 201 303) is responsible for dimerization.

There is no obvious, clearly defined peptide binding cleft on the surface of TtrD.

During the simulation, DNA initially enters into the binding cleft between the TRD and the catalytic loop.

Such an interaction between the C-terminus and the ssDNA-binding cleft is suggested to create an electrostatic shield that protects the binding cleft from random charged surfaces inside the cell.

However, instead of mainly occupying the peptide binding cleft, the compounds were preferentially docked perpendicular to this cleft, extending into a hydrophobic pocket in the Zn2+ domain.

Poses with RMSD<3.0 Å were energy-minimized in the protein binding cleft using the MMFF94x force field in MOE.

The presence of the GαCT2 peptide in the cytoplasmic G protein binding cleft moves the cytoplasmic end of TM7 slightly toward the center, leading to a somewhat narrower binding cleft.