Sentence examples for binding cleft which was from inspiring English sources

Electrophoretic mobility shift assay and crystallographic examination [ 65] have shown that 4OH-TAM-bound ER could not bind a GRIP1 coactivator LXXLL peptide due to helix-12 interference at the binding cleft, which was recruited by E2.

In addition, M561 pushes two water molecules and K514 out of the binding cleft, which was observed in the TKI258-WT FGFR1 KD structure (Fig. 2B, right panel and C, left and middle panels).

Strikingly, seven of the VirB4b-specific substitutions alter critical residues in the NTP-binding cleft, which is essential for T-DNA export in A. tumefaciens [41], casting doubt on the ability of VirB4b to function as a T4SS ATPase.

Also reported in Table 3 is the percentage change in hospitalizations with oral clefts relative to the control group without clefts, which are also depicted in Figures 2 and 3 for the overall cleft status and cleft type effects, respectively.

Most characteristic is the nucleotide-binding cleft which divides the protein in roughly two halves.

There are four cysteines that line the known NS3h nucleic acid binding cleft, but there are also three near the ATP binding site, which is known to modulate nucleic acid binding.

Such modifications can be further extended to exploit the nearby auxiliary cleft of the FAD-binding pocket, which is enriched in polar amino acids.

G1406 is predicted to be in the "switch 1 domain" of the cleft domain, which is thought to be important for the Pol II conformational changes that allow template binding (Gnatt et al. 2001).

Marintcheva et al. [30] showed that the acidic C-terminus of T7 gp2.5 and ssDNA actually compete for binding to the ssDNA-binding cleft of the protein, which is located in the N-terminal OB-fold domain.

The fourth change (K145N), which was located within a glycosylation site, may enhance viral binding since the smaller asparagine R group is located close to the HA receptor-binding cleft.

These inhibitors can inhibit various CDKs by targeting the ATP binding pocket of CDKs, which is located in the deep cleft formed by N-lobe, C-lobe, and the hinge region in CDKs[1], [33].