Sentence examples for binding cleft toward the from inspiring English sources

A glycine-rich loop acts as a lid, protecting the nucleotide's phosphates that protrude from the binding cleft toward the substrate from hydrolysis.

Modeling the missing residues in the human pol γ-α structure based upon the secondary structure prediction algorithm built into the I-TASSER server resulted in two short alpha helices connected by a short loop, which orient this element toward the DNA binding cleft of the enzyme (fig. 4 B).

The presence of the GαCT2 peptide in the cytoplasmic G protein binding cleft moves the cytoplasmic end of TM7 slightly toward the center, leading to a somewhat narrower binding cleft.

ITC-NAC metabolites oriented into the binding cleft with the negative-charged carboxylate group pointing toward the positively-charged surface between HDAC3 and SMRT (Fig. 8A D).

However, instead of mainly occupying the peptide binding cleft, the compounds were preferentially docked perpendicular to this cleft, extending into a hydrophobic pocket in the Zn2+ domain.

Clear electron density was observed for those ligands bound in the canonical binding cleft of the Bet v1 fold (Supplementary Fig. 7a). Figure 3: Crystal structure DtHNL1.

Structural analysis revealed a substrate binding cleft in the PDE domain, juxtaposed with the catalytic site, that is essential for positioning serines for ubiquitination.

Poses with RMSD<3.0 Å were energy-minimized in the protein binding cleft using the MMFF94x force field in MOE.

There is no obvious, clearly defined peptide binding cleft on the surface of TtrD.

Then, a DNA binding cleft emerges after the catalytic loop changes its conformation.

Since 385/388 face outside of the T strand binding cleft they cannot cleave the T strand downstream of -5 since it lies inside the cleft.