Sentence examples for binding cleft on the from inspiring English sources

Our lab has previously generated a knock-in mouse model (Rb1ΔL) to disrupt the LXCXE binding cleft on the retinoblastoma tumor suppressor protein [28].

There is no obvious, clearly defined peptide binding cleft on the surface of TtrD.

During this stage, CD74 is broken down in stages by proteases called cathepsins, leaving only a small fragment known as CLIP (class II associated invariant chain peptide), which maintains blockage of the peptide binding cleft on the MHC molecule.

The pre-crRNA is engaged in a binding cleft on one side of the protein and cleaved in the active site on the other side of the enzyme.

Transmembrane helices created an approximate circular pattern to form a substrate binding cleft on one side of the membrane.

The catalytic domain of ChiA1 consists of a deep substrate-binding cleft on the top of its 8-barrel structure.

Therefore, overall it appears that the CID may enhance the exo-type activity by forming a deep substrate-binding cleft on the top of the TIM barrel [39], [43], [54].

It is arguably safe to assume that the binding cleft on a receptor harbours sufficient information to encode the shape complementarity between the ligand and the receptor, and thus, ligand ligand structural similarity should imply pocket pocket similarity, and vice versa.

Clear electron density was observed for those ligands bound in the canonical binding cleft of the Bet v1 fold (Supplementary Fig. 7a). Figure 3: Crystal structure DtHNL1.

This in turn, resulted in the formation of a relatively deep-binding cleft on which the N-degron-recognizing and -binding functions likely emerged.

When a cofilin protein binds to an ATP-binding cleft on an actin filament helix, it changes the twist of the helix [19], and then bends the filament, thus accelerating actin filament severing [20].