Sentence examples for binding cleft of the from inspiring English sources

Thus, the nbs1-2 mayalter may althe the way in which proteins bind to the phosphoprotein binding cleft of the FHA domain, which in turn may either prevent the conformational changes associated with Ctp1 binding or inappropriately transmit information regarding the binding state of the protein to the BRCT domains.

Prediction of MHC-II epitopes is particularly challenging because the open binding cleft of the MHC-II molecule allows epitopes to bind beyond the peptide binding groove; therefore, the molecule is capable of accommodating peptides of variable length [ 1].

Prediction of MHC-II epitopes is particularly challenging because the open binding cleft of the MHC-II molecule allows epitopes to bind beyond the peptide binding groove; therefore, the molecule is capable of accommodating peptides of variable length.

In addition, conformational rearrangements are seen in a disulfide bridged surface loop (Cys141 Cys148), which moves inwards, partially closing the open substrate binding cleft of the native enzyme.

The amino acids at several positions within the peptide binding cleft of the DR molecule showed significant associations (p < 0.001) with the level of antibody response.

Taken together, we count the recognition of the target residue by the canonical binding cleft of the DDL FHA domain as the key molecular event to instate FHA domain-mediated protein protein interaction in plant miRNA processing.

Binding regions of type I and type II inhibitors in ATP-binding cleft of the kinase are indicated in Fig.  2.

The Fab fragment of K42-41L, that binds a loop on rhodopsin, was crystallized with a peptide mimic of the epitope that fits snuggly in the peptide-binding cleft of the antibody.

Marintcheva et al. [30] showed that the acidic C-terminus of T7 gp2.5 and ssDNA actually compete for binding to the ssDNA-binding cleft of the protein, which is located in the N-terminal OB-fold domain.

In this protein, it is known that the peptide region in the C-terminal half constitutes the outer walls of the substrate-binding cleft of the active site, which provides specific interactions that are critical to the selectivity of substrates and to the mechanism of molecular recognition by the enzyme [52].

The most common SPOP point mutation in prostate cancer involves the substrate-binding cleft of the gene.