Sentence examples for binding cleft and also from inspiring English sources

Similarly, the authors should add a sentence or two that helps the general reader to understand that Ran GTP) binds on the interior of the Crm1 solenoid and stabilizes a strained conformation that creates the hydrophobic NES binding cleft (and also comment on whether the Ran GTP) complex is required to explain the observed EM density).

As the self-peptide is usually 8 10 residues long, the two polypeptides (approximately 270 residues) form the binding cleft and are also bound to β2-microglobulin β2-microglobulinately 90–100 residues [7].

Residues 385 and 388 face away from the T strand binding cleft, while 394 faces into the T strand binding cleft and 393 is in an intermediate position.

In the HSP70 system, ATP binding brings about a conformational change in the HSP that exposes its peptide binding site, allowing peptides to enter the binding cleft and ATP hydrolysis to ADP then closes this cleft [ 28, 30].

In some synthetases, the tRNA binding event alters the conformation of the amino acid binding cleft and yields changes in amino acid substrate binding affinity.

In rice BGlu1, an extended loop comprising residues 322 335 delineates the far "plus end" of the binding cleft and its tip folds to form one side of the substrate-binding cleft.

Structural architecture of these motives presented that those motifs make a border to ATP binding cleft and project some residues into the nucleic acid binding site.

These subgroups differ in the architectures of their substrate-binding cleft and, thus, their enzymatic activities (exo vs. endo) and also contain different carbohydrate-binding modules (CBM 18 and 50; see also www.cazy.org; Gruber and Seidl-Seiboth 2011; Seidl 2008).

This prevents the antigen from exiting the binding cleft, while also serving as a signaling trigger to T-cells resulting in an immune system response.

These subgroups differ in the architectures of their substrate-binding cleft and, thus, their enzymatic activities (exo vs. endo) and also contain different carbohydrate-binding modules (Gruber et al. 2011; Seidl 2008).

Structure comparison of the GNE kinase domain with previously studied proteins revealed potential substrate binding sites at the interlobar cleft and also the structural and functional importance of the signature zinc-binding motif of the ROK family.