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Comparative docking studies were carried out to explore inhibitor binding characteristics within the X-ray structure and the model.
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These binding characteristics explain the differences seen in the cleavage assays, with the perturbed binding of Cas9 tracrHyb.v2 crHyb showing reduced in vitro cleavage efficiency.
Next, we sought to humanize mAb 85RF45.1, introducing as much human sequence as possible while retaining sequences that preserve the binding characteristics of the antibody.
The binding characteristics of the oligopeptide chemoattractant receptor on guinea pig macrophages and macrophage membrane preparations were characterized using detailed binding studies and computer analysis.
The oxygen binding characteristics of the isoforms in this case seems to depend on several concomitant amino acid exchanges within the hemoglobin molecule [18].
The binding characteristics as well as the size and morphology of the MIPs were examined.
Still, "challenges remain in the form of tuning the binding characteristics of both 'sides' of the molecule and optimizing 'linker' design," the venture capitalist said.
To understand the binding characteristics of elicited anti-Pfs25 SMFA-active antibodies, we performed binding kinetics analyses of the 10 Fabs to Pfs25 by biolayer interferometry (Supplementary Fig. 4).
Equilibrium binding experiments are conducted to evaluate the binding characteristics of MIPs and templates (BPA and 2,4-D).
The binding characteristics of secretin were most consistent with a single site receptor model.
Next, we evaluated the binding characteristics of 4-[18F]FEBZA to B16F1 cells through internalization experiments [33, 34].
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