Sentence examples for binding channel in both from inspiring English sources

The recognition of a larger hydrophobic substrate is reflected in the hydrophobic make-up of the substrate binding channel in both enzymes.

The studies presented in this work give important insight into the substrate and oxygen binding channels in the enzyme.

These findings give evidence of different locations of the oxygen and substrate binding channels in the enzyme and the origin of the separation of the oxygen-bound intermediates in the catalytic cycle from substrate.

Composed of Yku70 and Yku80 subunits in budding yeast, Ku binds DNA ends with high affinity via a preformed DNA-binding channel in a sequence-independent manner (Walker et al. 2001).

Furthermore, it was shown that binding of release factors induces conformational changes in both 40 S and 60 S subunits affecting the entrance of the mRNA-binding channel in the 40 S subunit and the two stalks of the 60 S subunit.

The aggregation pathway of TTR into amiloid fibrils is not yet well characterized but in vitro binding of thyroid hormones and other small organic molecules to TTR binding channel results in tetramer stabilization which prevents amyloid formation in an extent which is proportional to the binding constant.

The DNA lies in a binding channel around the surface, and both nucleic acid backbone and bases interact with the protein.

Noticeably, inhibition of EphA4 by a small molecule, called C1, which targets the EphA4 ligand binding channel rescued the disease phenotype in ALS models.

The R1 element of the regulatory segment leads into a helical R2 element that blocks the substrate binding channel of the kinase domain in the inactive form.

An example of how binding of butein (cyan sticks) physically obstructs the placement of fatty acid (modeled as green sticks) in the substrate binding channel is shown.

Furthermore, these data provide physical evidence that the target site for the inhibitors is not in the T/P binding channel of 3Dpol.