The prime minister's requests for "legally binding changes to the terms" of the Irish backstop were rebuffed repeatedly after she held talks in Brussels with Jean-Claude Juncker, Donald Tusk and other senior EU officials.
FXR is known to accommodate a flexible ligand binding domain, where ligand binding changes the position of the AF-12 helix and thus the recruitment of co-activator or -repressor proteins.
Lipophilicity-dependent protein binding changes the slope of the decreasing linear part, as can be seen in Figure 24.
The dTTPase mechanism of T7 DNA helicase resembles the binding change mechanism of the F1-ATPase.
Several reactions are needed to induce the phosphorylation of EGFR: ligand binding, conformational changes of the EGFR, EGFR dimerization, kinase activation.
To uncover the receptor binding changes during the evolution of the Fujian-like viruses, the binding strengths of HA to both the human and avian receptor analogs were calculated for each of the 207 virus isolates.
This energy-transduction process is reminiscent of the binding-change mechanism of the F1Fo-ATP synthase, which also utilizes the energy harnessed from the transmembrane electrochemical proton gradient to release synthesized ATP molecules from their binding sites in the α/β subunits (Boyer, 1997; Pos, 2009).
Ca2+ binding causes structural changes of the Ca2+-binding loop and the coordinated movements of two α-helices [32], with the C-terminal helix connecting to the linker region.
Indeed, recent measurements of AcrB transport kinetics (Nagano and Nikaido, 2009; Lim and Nikaido, 2010) are consistent with a bi-site activation model (Pos, 2009), analogous to the binding-change mechanism of the ATP synthase (Boyer, 1997).
A comparison of the chemical binding energy change of the pristine CDHA, pristine CS, and CS37 nanocomposites was shown in the ESCA spectra.
