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EM structures of RSC and SWI/SNF reveal a large binding cavity that can accommodate a nucleosome (Tang et al., 2010).
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Our structural data highlight several features of the WDR5-binding cavity that can be exploited to design in greater potency and cell permeability.
The GluA2 LBD dimer interface forms a large symmetrical cavity that can bind allosteric modulators.
The shape of the walls means there is a natural cavity that can be filled with insulation.
The pygidium possesses a complex nervous system with its own peripheral ganglia, a complex musculature and a cavity that can be identified as a true coelomic cavity.
And kneecaps have sac-like cavities that can be easily traumatized, Dr. Fodor said.
Unless crystal information is available, water molecules are placed in all cavities that can fit one.
This approach is attractive because joints are discrete, accessible cavities that can be readily injected.
The pore radii of the TDG-bound and periplasmic-open crystal structures are both tightly sealed towards the cytoplasm and display central binding cavities that are separated from the periplasmic funnel by Phe 27 (Fig. 2D).
Mutational and computational analysis of A1-AR revealed a distinct conformation of the second extracellular loop and a wider extracellular cavity with a secondary binding pocket that can accommodate orthosteric and allosteric ligands.
Wang J, Kubes P. A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair.
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