Sentence examples for binding cavity of the from inspiring English sources
Further, it appears that majority of the putative sites lie near the substrate binding cavity of the GGT-protein.
The two molecules of DRV are related by 180° rotation and interact with each other in the binding cavity of the PRP51-D25N dimer.
Some of these substrates make fairly well-defined contacts with the binding cavity of the pump [ 8] while others may not.
This indicates that there is substantial contribution of divergent sites in defining the binding cavity of the GGT enzymes of these two clusters.
The binding cavity of the β-isoform overall is smaller (390 Å versus 450 Å, of which genistein occupies 236 Å) compared with the ligand-binding cavity in the E2/human ERα complex.
The binding of a drug to a target largely depends on the structural correspondence of the drug molecule and the binding cavity of the target molecule, which can be modeled in principle, given ample computational resources.
The amino acid differences observed in the binding cavity of this protein may be helpful in designing specific inhibitors against the mammalian and microbial GGTs.
The binding cavities of the two proteins have two entrances, separated from each other by helix 3, and forming one channel from one side of the protein to the asymmetric unit dimer interface.
These previous findings are supported by the differences in the ligand binding cavities of the respective GRY53/7HC complexes, as described in Table 3.
Triptofordin B1 could reduce the binding cavity of BACE1; the results reveal that Triptofordin B1 could bind to BACE1 and better than 1M7, which could be used as potential lead drug to design novel BACE1 inhibitor for AD therapy The authors declared that there is no conflict of interests.
