Sentence examples for binding cavity close to from inspiring English sources

As it has been already suggested that the BBB-ChT pore is extremely important for a translocation of positively charged drugs across the BBB, 22 the analyzed active substances occupied negatively charged portions of the pore within the same binding cavity close to the center of the transporting channel.

The best binding position for Pi was found to be located about 6 Å up from the bottom of the cavity, close to residue Arg-120.

Etrx2 has an unprecedented hydrophobic cavity close to the active site.

Residue Arg-120 may be found in TM1 inside the cavity, close to the Pi docking position.

Our analysis also shows that many sites predicted to be contributing to type 2 functional divergence are quite often found lining the substrate binding cavity and are close to the highly conserved known functional residues.

This substituent was located more external to the binding cavity and able to adopt different poses.

The positively charged Arg-201 may attract Pi in the cavity before reaching its binding position, close to Arg-120, in the intermediate conformation.

Coupled with opening and closing of FABP4, the ligand may exist in two different binding modes: close to the bottom of the cavity or close to the portal.

Differences in ligand specificities by these two proteins might be conferred by different residues in the binding cavity, which are located close to the C-terminal lids in AgamOBP1 and AaegOBP1: Leu-15 vs. Phe-15, Leu-19 vs. Met-19, and Ser-79 vs. Ala-79 (Fig. 5).

The engineered binding cavity is known to be polar, solvated and deeply buried.

A second group of mutations target residues M100 and S259 which are located close to the putative binding cavity, but predicted not to interact directly with PTC (Figure S3).