Suggestions(4)
Exact(4)
However, despite the same binding affinity, the latter mutant shows a strongly reduced binding capacity suggesting that binding site III serves as a recognition element for additional Gb3 molecules after the protein has been bound [12].
Exine fragments washed with organic solvents and salts retain their binding capacity, suggesting that adhesion does not require protein-protein interactions [ 1].
As shown in Figures 1f and g, all SPOP mutants (D1 D8) completely lost ER α binding capacity, suggesting that the integrity of MATH domain was critical for binding to ER α efficiently.
Initial attempts to immobilize the sdAb-aGST-MESNA to the CM5 Biacore chip using a standard amine coupling procedure resulted in a complete loss of GST binding capacity, suggesting that this classical amine coupling affects residues critical for antigen binding.
Similar(56)
In parallel, a recent study indicated that B-cell specificities in pancreatic TLO of NOD mice are skewed to enhance autoantigen-binding capacity, suggesting that TLO promote selection of autoreactive B cells [20].
The results of their analysis indicate that the reversion of the amino acid sequence for α domain does not change its foldability and metal-binding capacity, suggesting that the order of its sequence is not essential for the formation of a critical metal-tetrathiolate nucleus [11].
Thus, consideration of only the binding sites suggests that genes with similar binding properties are present in both species and that both humans and mice can detect Iva (possibly with similar capacity), in agreement with the finding of O'Connell et al. To date, the functional variability within and between OR gene repertoires has been assessed by considering overall protein similarity [7], [14].
The data obtained and shown in Figure 4 d) reveal that the protease has an effective capacity for iron binding, suggesting that its action as an antioxidant may be related to its iron binding capacity.
Evaluation of the changes in constant pressure heat capacities during binding suggest that solvent exclusion from the binding site does not account for the dramatic affinity enhancements observed.
This suggested that integration of TCII in the C-terminal of the OLEO impaired the B12 binding capacity of the chimer protein [16], [19].
This suggested that position −5 could increase DYNLL-binding affinity, but at least by the hitherto identified set of natural DYNLL-binders this capacity is not generally utilized.
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