We show that progerin tail has a reduced DNA/chromatin binding capacity and modified trimethylated H3K27 binding pattern, offering a molecular mechanism for heterochromatin alterations related to HGPS.
The lead candidate (coined A8A3), composed of histidine and phenylalanine mimetic components, showed high binding capacity and selectivity for binding mono- and multi-phosphorylated peptides at pH 3. Ligand A8A3 was coupled onto both cross-linked agarose and magnetic nanoparticles, presenting higher binding capacities (100-fold higher) when immobilized on the magnetic support.
Although yeast cell wall products have been in the market for a long time, their binding capacity and the mechanism of pathogen binding is still not well understood.
The substrate-binding cleft obviously has a binding capacity and, as shown, this region is highly variable.
We demonstrated that B-CK showed a high I2 binding capacity and this specific binding was abolished by pre-treatment with an irreversible I2 selective ligand, BU99006.
More than 90% of ICU patients have low serum iron, total iron binding capacity, and iron/total iron binding capacity ratio, but have a normal or, more usually, an elevated serum ferritin level [ 2, 16].
Thus, eIF4E binding capacity and cytotoxic activity are tightly linked.
The MIP microspheres prepared via RAFTPP have proven to show improved binding capacity, larger binding constant and apparent maximum number for high-affinity sites, and significantly higher high-affinity binding site density in comparison with the MIP prepared via TRPP.
Nevertheless the increased peptide binding capacity, increased binding rate and decreased pH dependence of peptide binding as compared to mammalian-derived DR1 indicate that, as isolated, the antigen binding site is largely empty (>85%) [43].
Taken together, SrbA has high-affinity binding capacity to binding sites in hapX, hemA and srbA.
