An increased iron affinity by the reticulo-endothelial system and a decreased total iron binding capacity is associated with acute and chronic inflammatory diseases and may also induce iron deficiency and subsequent anemia.
The aim of this study was to examine whether in vitro assessment of GC sensitivity of PBMCs, using both these bioassays and measurement of GC binding capacity, is associated with the in vivo response to GC treatment in patients with RA.
As previous studies have shown reduced drinking capacity in FD patients compared to healthy subjects [ 17, 28], the finding that reduced D2R binding is associated with reduced drinking capacity would further suggest that an increased basal dopaminergic tone may be involved in the pathogenesis of FD.
Although it is not possible to measure SERT availability in the striatum using [123I]β-CIT, midbrain [123I]β-CIT binding is mainly associated with the binding to SERT, while binding in the striatum is mainly associated with binding to DAT [24].
Moreover, D2R binding was positively associated with drinking capacity in FD patients.
Lox, Sparc, and Sod1 genes with copper-binding capacity have been associated with angiogenesis (Lane et al, 1994; Juarez et al, 2006; Shieh et al, 2007).
