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Both prodrugs showed significant binding capability to hydroxyapatite, the major component of bone, and were hydrolytically activated under physiological conditions.
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These two binding sites confer the three GI NoVs a common binding capability to the A, H and secretor Le (SeLe, Leb/y) antigens.
Whether this susceptibility is due to an alternative structure or reduced binding capability to Hfq is unclear.
It is clear that these dual tags did not negatively impact the protein activity (fluorescence) or binding capability to GSH.
Upon sulfation of the four glycodendrimers, binding capabilities to the recombinant HIV protein, gp120, were assessed using an ELISA assay.
Microspheres demonstrate an increased binding capability compared to the homogenates.
The hydrolytically stable polyacrylamide phosphonates with their excellent binding properties to hydroxyapatite make them potential candidates for adhesives.
Bisphosphonates (BPs) are the most widely utilized bone-targeting ligand due to exhibiting high binding affinity to hydroxyapatite mineral.
All of the dendrimers exhibited more than 80% binding rates to hydroxyapatite (HAP), especially the [G2]-dendrimers (2a and 2b) showed dramatic binding rates (>95%).
Bisphosphonates have a high binding affinity to hydroxyapatite in bone and are therefore taken up preferentially by the skeleton.
The binding affinity to hydroxyapatite determines attachment to bone and duration of effect, and the inhibition of FPP synthase determines antiresorptive potential.
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