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This may reflect heterogeneity in their binding sites on integrins, since multiple sites enabling direct or indirect binding can result in a variety of dissociation rates [3].
MYT1/MYT1L binding can result in the recruitment of histone deacetylases (HDACs) to target gene promoters, which results in transcriptional repression [15]; the resultant loss of MYT1 function may be compensated by MYT1L activity [16].
Decreased protein binding can result in higher free-drug concentrations, and organ dysfunction may decrease drug metabolism and clearance [ 33].
This exponent is related to the number of activator proteins that form a transcriptional complex, and cooperative binding can result in Hill coefficients larger than 1.
Off-target binding can result in additional toxicity of these compounds in the clinic and also prevents the use of most ATP-competitive inhibitors as biological probes.
Alteration of the microenvironment of the fluorescent moiety on target binding can result in a shortening or lengthening of the fluorescence lifetime.
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Such a multiply membered set of object classes is represented as a union of classes, so this assertion indicates that a protein-binding process can result in the binding of either a protein, a protein polypeptide chain, or a protein complex.
The presence of an SNP on a binding site can result in several different effects.
Similarly, hydrophobic surface patches or promiscuous binding sites can result in soft interactions.
The sensitivity of primers to sequence variation in primer binding sites can result in incorrect genotype assignment as described in Gaedigk et al. (2010).
In conformational selection, addition of binding partners can result in a population shift in the conformational ensemble of a disordered protein (see section 4.2) toward the conformation that is most favorable for binding.
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