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Gulati et al. [ 17] suggested that hVps34/CaM binding can be disrupted by lengthy washes in EGTA, which leads to a loss of hVps34 activity.
Furthermore, the binding can be disrupted by exogenous KENIIF (but not KENII) peptide, strengthening the conclusion that this pathogenic region of CFTR binds IgG.
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In this report, we have demonstrated that the binding between FAK and p53 can be disrupted within a small molecule mimetic that targeted their interaction site.
As pre-miRNA hairpins can be bound by ADARs it is possible that their export from the nucleus, which is mediated by Exportin 5 (Yi et al, 2003), can be disrupted by binding.
Moreover, this phosphorylation can be disrupted by RNA binding.
The binding between Mms2 (a yeast homolog of UEV-1) and Ubc13 can be disrupted by mutating the eighth residue (Phenylalanine) of Mms2 to Alanine [89].
Using these tools, we now demonstrate that D1 D2 dopamine heterooligomers can be disrupted and the component receptors separated by dopamine and selective agonists that occupied one or both binding pockets.
Therefore the continuity of the IAN can be disrupted.
This complex can be disrupted by p53.
Daily activities and work can be disrupted.
Such relationships can be disrupted when parents separate.
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