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Similar ligand binding can also occur between different proteins that have a similar spatial arrangement of secondary structure elements around the ligand binding site ("ligand-sensing cores") independent from the overall fold [2].
Because of increased permeability, Annexin V binding can also occur during cell necrosis, and uptake of DNA stain TO-PRO-3 is tasen as a parameter to distinguish necrotic, and thus permeable, cells [ 11].
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This selection requires the presence of sequences within the target mRNA which are imperfectly complementary to the miRNA sequence; miRNA binding sites commonly occur within the 3'-untranslated region (UTR) of the mRNA, but functional miRNA binding sites can also occur with the 5'UTR [ 7] or coding region [ 8].
However, functional miRNA binding sites can also occur within the 5' UTR [8] or coding region [9].
However, misincorporation can also occur by binding and aminoacylation of any of the tRNA Pro by non-proline specific aaRSs.
However, some bulky DNA lesions cause conformational variation in the DNA that can also occur upon binding with a polymerase, which introduces additional challenges to the use of this method.
Of course, functional specificity can also occur post-DNA binding because the two HATs only share extensive, but not complete, homology.
20 Regional relationship between various elements can also occur, eg, TF binding sites are commonly located in the promoter region of genes, and thus identification of TF binding sites could benefit from knowledge the promoter region and vice versa.
More significantly, our results indicate that the interplay between multivalent binding and shear force can reproduce the shear-enhanced binding phenomenon, which suggests that under certain conditions, this phenomenon can also occur in systems that do not show a catch-bond behavior.
Change can also occur rapidly.
Other problems can also occur.
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