An HIV antibody achieves potency and breadth by binding simultaneously to two conserved glycans on the viral envelope protein.
A MAb elicited by 426 MCP demonstrates a similar breadth of binding to oligomeric gp120 on cells infected with viruses from different clades, and actually detects virus at a higher intensity and on more cells infected with a clade D isolate than does the MAb b12 (Table 5 and Figure 8).
We searched such deduced hypostatic regulatory relation of a TF-gene binding pair by the modified breadth first search (mBFS) algorithm [ 18].
Some of the protein family members represent isozymes, sequence similar enzymes that catalyze the same reaction but with definable differences such as substrate breadth, feedback inhibition, binding constants, reaction rates and the like.
One way to increase the likelihood of a quorum is to increase the length or breadth of the ice-binding site through natural selection or protein engineering.
It is possible that the greater breadth of zinc finger protein binding may lead to differences in toxicity and carcinogenic potential.
For HIV-1, information derived from structural studies of Fab fragments of V3-specific antibodies, combined with the determination of the crystal structure of the V3-containing gp120 core, have contributed to a better understanding of epitope binding and of the structural basis for neutralization breadth [17], [18], [19], [20], [21], [22], [23].
We predict that additional mRNA-binding proteins will also bind and be regulated by metabolites, increasing the breadth of the mRNA metabolite regulatory network.
This Ab exhibits stronger binding to Env VLPs, comparable ADCC potency but less breadth in comparison to the two CD4i Abs.
However, the breadth of antibody inhibition against different CSA-binding parasite lines was not examined, and overall there has been limited characterization of multidomain VAR2CSA immunogens.
