HapX interacts with the 5'-CCAAT-3' binding box in A. nidulans [ 30].
In addition, abrB310 and abrB3647 contain Spo0A-binding box in their promoter regions [ 68].
Our findings suggest that FNR is involved in this inhibition, probably indirectly, due to the absence of putative FNR binding-boxes in the promoter region of these genes [ 20].
True, last Dec. 31 we celebrated in every time zone, stuffed the earth with time capsules and vowed fervently to avoid the worst errors of the thousand years past, such as crusades, foot binding and wine-in-a-box.
(B ) A close-up of the MELT-binding region boxed in A. DOI: http://dx.doi.org/10.7554/eLife.01030.012 The side chains of the MEMTP motif are also extensively involved in the interaction with Bub3.
To validate this prediction, we used motif-discovery program nminfer (see Methods section) to identify c-Myc binding motifs/E-boxes in the ChIP-seq binding loci.
It is not yet clear if this is a direct effect, although both human and mouse Pax9 promoters contain putative T-box binding sites in an area of sequence homology (>80%).
Other transcription factor binding sites suggested to contribute to basal as well as iron-overload induced hepcidin expression are a C/EBPα binding element and the upstream stimulatory factor (USF) binding site/E-box in the proximal promoter [15], [16].
Three consensus E-boxes for Snail binding exist in a 0.5-kb fragment upstream of the Vdr coding region (Cano et al, 2000; Figure 5C).
Consistently with this, aside from the two Sp1-binding GC-boxes mentioned above, we found two NF-Y-binding CCAAT-boxes in the vicinity of the SREBP-binding site of the DHCR24 core promoter.
It is difficult to reconcile this model with the observation that younger Alus are enriched for the short spacer binding sites in the A-box region that appear to have evolved via CpG methylation and deamination.
