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The myc gene family is only a subset of a much larger super family of genes that encodes DNA binding basic helix-loop-helix proteins (bHLH).
The Id proteins lack the DNA binding basic domain but have intact HLH domain [ 2, 3].
Id proteins inhibit transcription by binding basic helix-loop-helix (HLH) transcription factors through their HLH motif.
It has been shown that calcium-sensor protein calmodulin can interact with the DNA binding basic helix-loop-helix (bHLH) domain of TCF4 inhibiting its transcriptional activity [ 95].
The transcription factor N-myc, which is encoded by the human MYCN proto-oncogene, belongs to the Myc family of DNA binding basic region/helix-loop-helix/leucine zipper (bHLHZip) proteins in which c-Myc, L-Myc and N-myc are the best characterised members (Meyer and Penn, 2008).
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These Uba1 and UBA3 helical insertions would clash with the Uba2-binding basic residues from Ubc9's α-helix1 and extended β1β2 loop.
An N-terminal phospholipid-binding basic domain (BD) has also been identified in the Drfs mDia1 and mDia2.
Plant bZIP proteins characteristically harbor a highly conserved bZIP domain with two structural features: a DNA-binding basic region and a leucine (Leu) zipper dimerization region.
Shown at the top are the boundaries used in this study to distinguish the DNA-binding basic region, the two a-helices and the variable loop region.
As the probe is partial without the region coding for DNA-binding basic amino acid rich domain, the larger transcript (2.2 kb) did not hybridize.
Circadian transcription of per and cry genes is mediated by an E-box-binding basic helix-loop-helix transcription factor consisting of CLOCK (or NPAS2) and BMAL1.
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