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Nevertheless, using a two-tissue compartment model (which showed a better goodness-of-fit than one-compartmental model), we found no evidence of specific binding based on the blockade studies.
Here we report a non-radioactive assay for quantification of cell-surface DNA binding based on the isoparametric analysis of flow cytometric data as described by Chatelier et al., Embo J., 5 (1986 11811986 1181
The mechanism of membrane binding based on the detection of membrane curvature is likely to be relevant to GMAP210 function.
Arsenite or ATO showed no effect, which is consistent with the lack of binding based on the selectivity data.
This finding can also explain the significant quantity of transcripts from SGFRm (20.7%, Additional file 1) categorized such as "nucleic acid binding" based on the GO database.
Following the editor's recommendation we have constructed a null model for random ribosome binding based on the signal in annotated 3'UTRs.
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Although the receptor blocking studies showed no displaceable (i.e., no specific) binding based on peak uptake, the images were more accurately quantified using the entire scan duration and correcting for delivery of radioligand to brain, namely, compartmental modeling.
We also propose the structural basis for the CP04-CCK2R basedng based on molecular modeling of the peptide-ligand interactions.
Green checks indicate residues involved in the binding, red crosses residues that are not involved in the binding, based on experimental data.
The main point of the design was to fill the interdomain cavity of GluA2 ligand binding domains based on the cyclothiazide binding mode.
A model of the GABAC receptor binding site, based on the structure of the acetylcholine binding protein AChBP, indicates that the site is dominated by aromatic amino acids.
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