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How does evolution optimise the binding attributes of a motif?
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This could be the result of each monomer cancelling out the negative binding attributes of the other.
In summary, the unique evolutionary and binding attributes of motifs in DNA, RNA and proteins facilitate two highly exploited mechanisms: (i) the co-operative use of multiple independent low-affinity and low-specificity binding sites to allow highly specific assembly of dynamic, meta-stable complexes, and (ii) the co-operative integration of information in conditional decision-making interfaces.
The higher temperature resulted in an increase in chloride binding; attributed to greater degrees of slag hydration.
This attribute of a weak-binding affinity renders SLiM-mediated interactions difficult to detect experimentally (Diella et al., 2008).
Cell responses to EDPs were attributed to the binding of a VGVAPG hexapeptide sequence, repeated several times in tropoelastin, to elastin receptors with lectin-like properties, named the elastin receptor complex (S-Gal/neuraminidase/ cathepsin A protective protein) or galectin-3.
It uses a stacked architecture, where PONDR® VLXT is used to identify short predictions of order within long predictions of disorder and then a second level predictor determines whether the order prediction is likely to be a binding site based on attributes of both the predicted ordered region and the predicted surrounding disordered region.
The predictor utilizes a stacked architecture, where PONDR® VLXT is used to identify short predictions of order within long predictions of disorder and then a second level predictor determines whether the order prediction is likely to be a binding site based on attributes of both the predicted ordered region and the predicted surrounding disordered region.
Alternatively, not the binding pocket, but the chemical attributes of the odorants might cause asymmetry in generalization.
Compared to GST-FlpA, significantly less GST-FlpA-D1 and GST-FlpA-D3 bound Fn-coated wells and did not exhibit attributes of specific binding.
In conclusion, the PLIC database provides clusters of binding sites along with information about similarity among members within a cluster, common interactions in the cluster through alignments of sites, protein ligand contacts, binding site environment properties and binding energetics that help in analyzing various attributes of protein ligand interactions.
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