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Our class averages at the moment lack the resolution and signal-to-noise ratio to be unambiguous but they suggest the following properties of the weak binding attachment that precedes strong binding.
The binding attachment system will be one of two: Ask for advice.
The binding attachment system will be one of two: This provides the flexibility of the snowshoe, or not as the case may be.
Bindings can be padded, shaped, insulated, in a variety of colors etc. and they range in type: Check the binding attachment system.
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However, when weak binding attachments are included, the shoulder at 110° is enhanced.
The results support previous conclusions that the weak attachments preceding force generation are very different from strong binding attachments.
Stress/strain in the S2 domain may explain azimuthal lever arm changes in the strong binding attachments.
The initial myosin crystal structures sit near one azimuthal extreme of our strong binding attachments (Fig. 5B).
There is little previously published information on the structure of weak actin attachments but strong binding attachments are well characterized from combinations of crystallography with cryoEM [5].
Type 1 weak binding attachments show a smaller azimuthal lever arm variation (Figs. 4A, 5B) than the strong binding heads that they evolve toward.
The lever arm azimuthal range of strong binding attachments has a highly skewed, 127° range compared with X-ray crystallographic structures.
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