Sentence examples for binding at this site from inspiring English sources
By conducting MD simulations on this structural model and evaluating the 2D PMF profiles of ion binding at this site, we successfully identified the essential roles of Lys and Asp/Glu in determining the Na+/K+ selectivity.
In order to test the hypothesis that binding at this site blocks 3Dpol polymerase activity, we generated the K59A and K177A mutants of 3Dpol and tested their susceptibility to three inhibitors (5D9, 1A8, and 8C5).
Treatment with mithramycin suppressed binding at this site.
The next binding motif contains the target residue Cys797, the N-substituted pyrazole derivatives, and six membered (dihydropyrimidine) are binding at this site.
Interestingly, in the case of the (α4 3 β2)2-TMD S --chiometry, (S)-- and (R --mecamylamine also pR --mecamylamine eneR --mecamylamine alsohis site (Table 1).
In previous work, we showed that a similar deletion of one of three histidines at the H-site was insufficient to abrogate copper binding at this site.
As with rs2382818, we were unable to detect a CREB1 binding motif at this site.
The protein binding activity at this site was validated but was not dependent on nitrate in the media [ 64].
Peptide inhibitors are designed to inhibit the action of cathepsin K by binding at this substrate site, mimicking a natural cathepsin K-substrate complex.
