Sentence examples for binding at this position from inspiring English sources

Glide-XP and quantum mechanics polarized ligand (QPLD-SP/XP) docking calculations revealed favorable binding at this position to be dominated by hydrogen bond contributions; none of the substitutions (including fluorine) out-performed the native –OH substituent which can act both as hydrogen bond donor and acceptor.

Therefore, drug binding at this position not only can hold the channel in the closed conformation but also can simply block the proton exits.

The inability of λcI to effectively act as a repressor when bound to a single operator at the downstream position is most probably caused by its inability to effectively compete with RNA polymerase binding at this position [13].

Binding at this position is consistent with in vitro studies, which suggest that chromatin remodelers initiate translocation on nucleosomal DNA at an internal position ∼20 bp from the dyad at superhelical location 2 (Saha et al., 2005; Zofall et al., 2006).

Interestingly, only BdCAD1 contains both active substrate-binding residues, W119 and F298, which determine specificity for aromatic alcohols, and the conserved S212 residue that determines NADP(H) binding at that position, as seen in OsCAD2 in rice [ 55].

5S rRNA contains several consensus Nrd1-binding motifs and sequencing data revealed nucleotide substitution in the second, and deletions in the fourth GUAA/G motif (deleted nucleotides underlined), indicating direct Nrd1 binding at these positions.

In contrast to compound 7, compound 8 showed a decrease in potency against TryR compared with M (M, IC50=10.9 μ m; 8, IC50=26.9 μ m, Table 2) suggesting that the phenylpropyl chain is better at binding in this position than the 1-cinnamyl chain.

There is neither an intrinsic reason for the head to pause there, nor is there a binding site present at this position.

Whereas an A>T substitution at position 7 permitted binding, an A>C substitution at this position abrogated DNA binding (Fig.  2E, lanes 1 3).

In contrast, the members that are more likely to be proton-coupled (those, for example, that lack Asp405, one amino acid whose side chain is clearly involved in Na+-binding) have Leu at this position.

The size of the pocket allows for binding of various ligands at this position in various orientations (see Supplemental Material, Figure S5).