Sentence examples for binding at this locus from inspiring English sources
ChIP analysis using a CLOCK antibody showed that decidualization was associated with a rapid and sustained loss of CLOCK binding at this locus (amplicon −301 to −162 bp).
Here, we demonstrate that it also true in the HCMV episome, with both H3K9me3 and HP1 extending to the MIEP in spite of the absence of direct KAP1 binding at this locus.
However, in both senescent and Polycomb mutant cells we observe a strong enrichment of MLL1 binding at the locus demonstrating that MLL1 participates to the transcription of Arf and Ink4a.
The RefSeq gene locus comprises a single exon and CAHM transcripts are unspliced; this, along with ENCODE data describing the histone marks and transcription factor binding at the locus are shown in Figure S1.
Ablation of either USP7 or USP11 in primary human fibroblasts results in de-repression of the INK4a tumour suppressor accompanied by loss of PRC1 binding at the locus and a senescence-like proliferative arrest.
Analysis with the TESS database revealed a strong GATA-3 core-binding site at this locus in the A allele (given in italics above), which was not present on analysis of the G allele.
Data directly assaying SP1 binding at these loci confirmed that binding was preferentially associated with the unmethylated copies of discordant CpG sites.
To test whether monoallelic expression of IGF2BP1 in some individuals is also regulated by monoallelic DNA methylation of CTCF binding motifs, we examined a role for CpG methylation and allele-specific binding of CTCF at this locus.
This is because DNA-binding proteins act at this locus to maintain heterochromatin after its establishment (Jia et al., 2004; Kim et al., 2004).
(A) Sir2-4p binding at HMR locus is dramatically reduced in spt16-m cac1Δ rtriple triple mutant cells.
This genotype was reported to be significantly overrepresented in BSE-affected cattle presumably due to the homozygous deletion of a PRNP transcriptional RP58 binding site [6], [7], [10], [20] at this locus.
