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This distance was chosen so that the probability of binding at this distance equaled 10−6.
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To uncover an explanation for how drug binding at a distance from the kinase active site could lead to inhibition and how inhibitors could combine their effects, hydrogen exchange mass spectrometry (HX MS) was employed to monitor conformational effects in the presence of both dasatinib, a clinically approved ATP-site inhibitor, and GNF-5.
From this analysis, we predict Creb, Tcf/Lef, Pou-domain containing transcription factors, Sox9, and Mef2a as novel co-factors (binding at a short distance) and co-regulators (binding at further distance) of proneural proteins.
These results are in agreement with the notion that CUX1 can perform some regulatory functions when binding at a distance from transcription start sites.
The maximum looping is achieved when the two binding sites are 306 bp apart, suggesting that at this distance, the two sites are in an optimal phasing orientation for binding of the two heads of Lac repressor.
Sounds OK to me at this distance.
"My hands are tied at this distance".
At this distance, and at shorter distances, Na+Cl− is the lower-energy species.
10 m distance includes all throws at this distance, including those with altered target height.
Legend, at this distance, leaves a few things out, though.
At this distance we got a good view.
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