Sentence examples for binding at these loci from inspiring English sources
Data directly assaying SP1 binding at these loci confirmed that binding was preferentially associated with the unmethylated copies of discordant CpG sites.
However, in both senescent and Polycomb mutant cells we observe a strong enrichment of MLL1 binding at the locus demonstrating that MLL1 participates to the transcription of Arf and Ink4a.
ChIP analysis using a CLOCK antibody showed that decidualization was associated with a rapid and sustained loss of CLOCK binding at this locus (amplicon −301 to −162 bp).
The RefSeq gene locus comprises a single exon and CAHM transcripts are unspliced; this, along with ENCODE data describing the histone marks and transcription factor binding at the locus are shown in Figure S1.
Here, we demonstrate that it also true in the HCMV episome, with both H3K9me3 and HP1 extending to the MIEP in spite of the absence of direct KAP1 binding at this locus.
Ablation of either USP7 or USP11 in primary human fibroblasts results in de-repression of the INK4a tumour suppressor accompanied by loss of PRC1 binding at the locus and a senescence-like proliferative arrest.
Figure 2E shows gene tracks of Tcf3, Nanog, and Oct3/4 binding at these five gene loci.
Importantly, these are candidate mediators in a therapeutic setting since both AR's binding and transcriptional activities at these loci were modulated by small-molecule antagonists.
Analysis of ChIP data of responsive and nonresponsive breast tumors [ 7] revealed significant differential ERα binding at several of these loci, with 10 of 27 showing increased binding in the nonresponsive setting.
Emerging evidence shows that the maternal genome, and certain paternal imprinted loci, are protected from Tet3-mediated hydroxylation by the binding of PGC7 to H3K9me2 at these loci [111].
Renda, M. et al. Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci.
