Sentence examples for binding at the site from inspiring English sources
These compounds could also be affecting AR binding at the site of action (Randall 2008).
We then model interference of the agonist with transcription factor binding at the site controlling transcription initiation.
Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility.
However, apart from a variant in the immunity-related GTPase family, M (IRGM) gene, which has been shown to confer susceptibility to Crohn's disease by altering miRNA binding at the site of the SNP [ 4], the causal genes and mechanisms in most cases remain to be identified.
A key aspect of the competitive binding model is mutually exclusive binding of PPARγ and AP-1 transcription factors at the DR-1/AP-1 element, and when considering the competitive binding model, one would expect a decrease in PPARγ binding at the site in cells treated with IL-1β as compared with rosiglitazone- or LG268-treated cells.
More importantly, we show that [Fe(IV =O Tyr71] is the reactive intermediate in the oxidation of guaiacol binding at the site remote from the heme, and that Trp51 is involved in the electron transfer pathway between Tyr71 and the heme.
Because the Ct site is observed only in the apo-like conformation, cation binding at this site would also inhibit the transition into the bound-like conformation upon Na+ binding at the Na1 site.
Thus by this molecular assay Rad51p binding occurs at the site of hybrid formation prior to hybrid-induced DNA damage.
(2011) that allosteric activation is due to binding at the tight site, whereas the effect on dephosphorylation is due to binding at the weak site.
This model suggests that it would be possible to develop agents that disrupt further polymerization by binding at the polymerization site.
Importantly, immunofluorescence staining and colchcine competitive binding assay revealed that microtubule dynamics was disrupted by 7e by binding at the colchicine site of tubulin.
