Sentence examples for binding at the peripheral from inspiring English sources

On autoradiography however, a focal uptake of 67Ga-P04087 in the valve area was present and histological slices demonstrated localization of peptide binding at the peripheral layer of vegetations.

The target compounds were designed as dual binding site acetylcholinesterase inhibitors with an arylalkylamine moiety binding at the catalytic site of the enzyme and connected via an alkyl chain to a heterocyclic fragment, capable of binding at the peripheral anionic site of AChE.

In ITC experiments, we saw no detectable binding when we added IP6 to a PH-TH module with mutations at both the canonical and the peripheral sites, which confirms that the residual binding of IP6 to the IP4-binding deficient mutant is due to binding at the peripheral binding site.

Molecular modelling studies suggest that these compounds might bind at the peripheral binding site of AChE, which opens the possibility to design inhibitors able to bind at both, the catalytic and peripheral binding sites of the enzyme.

Formation of the Saraste dimer is compatible with the simultaneous engagement of PIP3 by both PH domains in the dimer, and is compatible with the binding of IP6 at the peripheral binding site.

In ITC experiments, we saw no detectable binding when we added IP6 to a PH-TH module with mutations at both the canonical and the peripheral sites, further confirming that the residual binding of IP6 to the IP4-binding deficient mutant is at the peripheral binding site.

The canonical binding site and the peripheral binding site are shown in blue and magenta circle, respectively.

Arg 52 and Lys 49 are critical residues coordinating IP6 binding in the peripheral site.

This study also investigated inhibitor binding, although the peripheral adamantane site was occluded by detergent micelles.

IP6 binding to the peripheral binding site may also enhance PIP3 affinity in the canonical binding site and sensitize Btk to PIP3 levels.

(E ) An electron density map, using σA-weighted 2m|Fo| − D|Fc| coefficients (Read, 1986 ) for IP6 at the peripheral binding site, contoured at 1.5 σ.