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Additionally, subtle changes in dynamics at the second active centre may accompany binding at the first.
Thus, GCU is preferred by anticodon GGC because of the strong binding at the first two codon positions.
Nucleotide binding at the first subunit causes an 81-fold weakening in the affinity at the second.
Cartoon model depicting the destabilization of the L1':Fn2-3 interaftern after ligand binding at the first L1 Fn2'-3' site.
The KI for inhibition by ibuprofen and the Kd for binding of mefenamate suggest high affinity binding at the first COX-2 subunit.
PAPS binding at the first site closes both the nucleotide and acceptor cap segments only on the subunit to which PAPS is bound; the cap on the adjacent subunit remains open at both sites.
Similar(53)
Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ERβ binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line.
This phenomenon is expected since the Lac repressor exists always as tetramers under the conditions used here [47], [48], and competition for binding at the second operator between loose Lac repressor and Lac repressor bound to the other operator is stronger as the concentration of Lac repressor increases.
A weak binding at the third codon position is preferred, with strong binding occurring at the first two codon positions, and a strong binding at the third codon position is preferred, with weak binding occurring at the first two codon positions.
Depending on the organism, the number of different tRNA isoacceptors range from 23 (allowing for a fully degenerate binding at the third codon position) to 45 (allowing only degenerate binding of pyrimidines).
This process facilitates DNA binding at the second unit, which also bring DNA and the third subunit closer and the process repeats, leading to the translocation of the adjacent subunit along DNA.
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