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This treatment removed ∼53% of 'surface' DNA binding at the expense of a 9.3% loss in 'core' protein binding.
As ascertained by both seeding experiments and gel electrophoresis, fetuin-A is not only more dominant but it appears to compete avidly for nanoparticle binding at the expense of albumin.
IRP1 also responds to NO, which likewise induces IRE binding at the expense of its aconitase activity, albeit by a diverse mechanism.
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Attenuated metal-binding is believed to improve the selectivity and safety profile of CYP inhibitors, compared to azole antifungal drugs, by increasing contributions of specific drug protein interactions in binding affinity at the expense of nonspecific drug metal interactions via less avid metal-binding groups.
Because the binding of phenolic compounds to the cell wall is mediated by peroxidases and, during plant-pathogen interactions, this binding occurs at the expense of a massive generation of H2O2 [ 27], we monitored peroxidase activity.
These results indicate that we have reduced 42 false negatives by using relaxed P-value for binding data at the expense of increasing 14 "false positives" even if the high-quality ChIP-chip data are treated as gold standard dataset.
In other words, a stronger 'power-stroke' associated with ATP binding is achieved at the expense of reducing the hydrolysis power of the bound ATP.
INTS3 immunoprecipitation shows that this increased level of NABP1 leads to increased binding with INTS3, at the expense of NABP2.
Therefore, this increasingly validated set can be taken through to ITC to quantify the binding constant directly at the expense of relatively large amounts of protein and time.
The Fe-H bonds were formed, and their bindings were achieved at the expense of their Fe-Fe, Fe-Ni, and Ni-Ni first neighbors.
Subsequent characterization of the purified antibodies demonstrated that the ELP fusion does not interfere with antibody assembly in tobacco and endows the recombinant antibody with greater antigen-binding activity albeit at the expense of HIV-neutralization efficacy.
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