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We originally selected Ad2F as a mucosal targeting ligand and demonstrated its ability to mediate antigen binding at the epithelial surface in the mouse nasal cavity [7].
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The binding of prostate epithelial cells and melanoma cells also have induced raised intracellular Ca2+ levels (Pili et al, 1993), which correlated with increased binding of the epithelial cells.
This complexity arises in part from many observations suggesting that CFTR is part of a multimolecular complex in the apical membrane of epithelial cells containing (besides protein kinases) N-terminal inhibitory syntaxins, PKA-interacting ezrin binding phosphoprotein (6), and many others including CAP 70 (7) and more recently a cAMP-efflux pump binding at the C-terminus of CFTR (8).
It was hypothesized that blocking of the FimH binding pocket by preferential binding to a soluble mannose residue would reduce the binding to uroplakins on the epithelial cell surface of the bladder.
The Lewis Y antigen is expressed on the majority of human epithelial tumors, but normal human tissue also contains the BR96-binding antigen, primarily in the epithelial cells of the gastrointestinal tract [13].
Meningococcal colonization led to conspicuous epithelial damage and tissue atrophy especially at the olfactory epithelial region.
This vaccine targets the epithelial cell binding domain of the type IV pilus, a key adhesin of Pa.
During phagocytosis, C1q facilitates the binding to apoptotic epithelial cells by E. histolytica trophozoites [ 34].
The EK is formed by a clump of epithelial cells at the centre of the epithelial cap (Fig. 16c).
This binding then results in the modulation of Wnt activity in the epithelial cells.
Galectin-4 was shown to have the ability to enhance epithelial cell moving to this area through binding to cadherin/catenin complex at the surface of epithelial cells (Paclik et al., 2008b).
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