Sentence examples for binding at the distal from inspiring English sources
Conversely, a titration of ATP against protein preincubated with 5 m m fragment showed no effect on ATP binding at the distal ATP binding site.
Obtained data suggest that manipulation of proximal W145 and W146 only slightly affected cyanide binding at the distal side (Table 2).
Ectopically overexpressed FOXO3a or combined treatment with doxorubicin to induce FOXO3a nuclear accumulation leads to further binding at the distal FOXO3a site (-249 ~ -242).
The significant increase in the KM value of the variant E210A (382 μM) compared to the wild-type enzyme reflects a more than 5-fold decrease in chlorite binding at the distal heme cavity.
A similar effect might be associated with substitution of the invariant Tyr702, which is located within the REM domain at the interface with the CDC25 domain, in close proximity to the region of the latter that undergoes the conformational switch promoted by RAS binding at the distal site.
The results indicated many trans-acting factors binding the relevant elements in the gene sequence, with several HSF binding sites at the distal end and 6 SP1 and 2 NF-κB binding sites in the GC-rich region at the proximal end.
HDAC1 binding does not significantly change, but acetyl-HDAC1 binding increased at the distal site.
Rather, it binds at a site that is known to dynamically regulate binding interactions at the distal groove.
Its disruption significantly alters the redox properties of the heme iron as well as the ligand binding behavior at the distal side.
To gain an understanding into how iAs might impact TET expression, we found that iAs inhibits the binding of CTCF at the proximal, weak CTCF binding sites of the TET1 and TET2 gene promoters and enhances CTCF binding at the stronger distal binding site.
PapG, the Gal alpha 1-->4 Gal binding moiety localpha 1-->4 Galtalpha 1-->4 Gal fimbindingilamoietyappeared to be responsiblocatedthis effect becatse an isogenic PapG- muthet, E. coli ORN103/pPAP24, exhibitedistaling intendctiofs witheneutroPhils that were similar to nonfimbrialed E. coli ORN103.
