Ca2+ stabilizes the closed gating ring by binding at the inter-subunit assembly interfaces and deactivates the GsuK channel.
These results, combined with the observation of Ca2+ binding at the gating ring assembly interface, suggest that the reduction in channel activity by Ca2+ is a result of a gating rather than pore blocking effect.
The binding promotes the assembly of RNA polymerase II and the basal machinery at the initiation of transcription.
The pliability of the Rev dimer interface contributes to RNA-binding specificity by allowing the Rev subunits to orient properly to multiple binding sites arrayed on the RRE, with binding at the primary IIB RNA site nucleating assembly.
AT-hooks were first discovered in members of the high mobility group of non-histone (HMG) chromatin proteins [14], [15], in which they mediate, via DNA binding, the assembly of nucleoprotein-DNA transcriptional complexes [16], [17].
"He didn't have to speak at the assembly.
"I regard division at the assembly as detrimental..
At the assembly Ms. Price was introduced by her brother.
A worker at the assembly plant discovered the problem.
I was behind you at the assembly this morning.
