Sentence examples for binding at specific sites from inspiring English sources

The present work demonstrates that CuII binding at specific sites and moderately low dielectric medium guide the protein through well-identified aggregation pathways.

It is known that metal ions play an important role in stabilizing proteins, protecting against thermal denaturation by binding at specific sites [ 36, 42].

Given that we observed substantially larger differences in target gene expression in the same experiment, it is highly unlikely that dynamic binding at specific sites is the primary regulatory mechanism for the specific induction of cAMP-responsive genes by CREB in vivo.

TFs are special types of proteins that have DNA binding domains that can bind at specific sites of DNA defined by particular sequences of certain length.

In mature virions, in which NC is thought to coat the viral genomic RNA, NC binding was observed at specific sites that again included the 5′ UTR and the RRE.

Zonal elution competition studies were designed and carried out in both normal- and reversed-role formats to investigate the binding by this drug at specific sites.

As an example, phosphorylation at the Ser235, Ser404 and Thr50 sites may in fact promote microtubule binding, formation and stability at specific sites (38, 39).

For example, PARylation of KDM5B, a histone lysine demethylase that acts on histone H3 lysine 4 trimethyl (H3K4me3), inhibits KDM5B binding and demethylase activity at specific sites in the genome.

The Gaussian network model (GNM) has been shown to predict the protein residues located at specific sites for drug binding [30], [31], [32].

Especially for the function in excision repair a specific binding site seems counterproductive to the occurrence of mutations only by chance not at specific sites.

Notably, transcription factor FoxA1 is globally retained on mitotic chromatin as visualized by IF, even though its binding at specific binding sites as measured by ChIP is substantially diminished [ 20].