Sentence examples for binding at several sites from inspiring English sources
Ebf1, Ebf2, Olig3, Gata6, and Sox 2 display significant endogenous c-Myc binding at several sites within their promoters in mES cells (Figure 5 blue bars, Figure S10) consistent with our promoter array data (Table S1).
We thought our analysis might uncover a motif related to FruA binding, since FruA binds cooperatively with MrpC at several sites [ 45– 48, 53].
Chk2 phosphorylates p53 at Ser 20, inhibiting MDM2-p53 protein binding [ 16] but also at several sites located in the C-terminal domain of the p53 protein [ 17].
The diXVCA material is similar to diVVCA but has the first V domain mutated at several sites to reduce binding to actin.
Phosphorylation at several sites by the IKK complex increases the DNA binding and transcriptional activities of p65 [51], [55], [55].
The interactions of (S -- and (R --mecamylamine with seveR --mecamylamineteR --mecamylamineesolution NMR, within the hα4β2-TMD indicate different modeseveralnding at severesiduesnal (L) andeterminedal (NL) sites.
However, the binding pattern of CTCF at −31 is not defined by a single peak of enrichment in ChIP-chip - it is likely to bind to several sites over at least 2 kb interval centered at −31.
In fact, the WT1 TF binds at several G-rich sites (GNGNGGGNG), including the EGR1 consensus binding site GCGGGGGCG [ 7- 9].
Previous work had indicated, in the context of plasmid reporter genes, that loss of Abf1 binding sites at several memory effect genes resulted in strongly diminished transcription (Della Seta et al. 1990; Hornung et al. 2012; Lascaris et al. 2000; Yarragudi et al. 2004; Yarragudi et al. 2007).
However, the binding polypeptide is displayed in several copies at the phage surface and may bind the ligand at several different sites, and subsequently, the interaction may not easily be inhibited by free ligand even if added in excess.
