Sentence examples for binding at repressive sites from inspiring English sources

Since protein recognition motifs for histone binding at repressive sites are similar [ 33] and EHMT2 has been shown to be able to methylate H3K27, in addition to its more common H3K9 target [ 27], it is likely that there are common aspects to the histone substrate binding pockets of the repressive HKMTs EZH2 and EHMT1/2.

EphB4 ephrin-B2 binding occurs at sites of contact between cells.

Under these conditions copper binding might prevent iron binding at one or more sites.

Such a hierarchical decision could in principle be achieved by an alternative design: an intricate network of cross regulation, where a low-ranking sugar system is repressed by the regulator of the higher ranking sugar; this requires numerous repressive binding sites, especially at the lower ranking promoters.

We revisited their data and found that 5hmC was only present at sited lacking PolII occupancy (Additional file 1: Figure S6), indicating that 5hmC at PPARγ binding sites bears repressive roles in mature adipocytes.

We therefore propose a model in which JMJD2B at ER binding sites removes the repressive histone marks, which may also set up docking sites for enzymes and transcription factors that remodel chromatin or otherwise modify gene-control regions.

Furthermore, EBF1 binding to Gata3 regulatory sites induced repressive histone modifications across this region.

In addition, the epigenetic profile of a promoter region can influence binding, with repressive histone marks and nucleosome occupancy limiting access of transcription factors to their binding sites [ 32- 34].

The promoter was mutated at a single TCF4/Lef1 binding site or both binding sites at a time.

However, as noted already, a repressive binding site such as this does not change the underlying dynamics of ASO, nor does it dampen exponential amplification in the absence of ASO or a similarly effective mechanism.

Repressive chromatin at the transcription start site or at the binding sites of activation transcription factors prevents transcription (Tost 2010).