Sentence examples for binding at other sites from inspiring English sources

Sko1 binds constitutively to some genomic locations, while Sko1 binding at other sites is induced by stress (Capaldi et al. 2008; Ni et al. 2009).

Ligand binding to PID, mutations, or post-translational modifications away from the binding site allosterically alter the PID binding site conformation (12, 13). 2 provides two examples illustrating how binding at other sites by an RE (6) or agonist/antagonist ligand (14) can alter the respective co-regulator binding site conformations leading to activation or inhibition.

Consistent with these mutagenesis data, calcium occupancy at the Ca3 5 sites is reduced (60 80%) in the D177A·Ca(10mM)2+ structure, whereas calcium binding at the other sites is unaffected.

This data clearly indicates that upto 8  μM curcumin, there is strong binding and internalization of curcumin in the hydrophobic region of RNase L, but above 8  μM, there is a change in conformation probably due to binding of curcumin to different residues at some other sites.

Autophosphorylation of FAK provides a binding site for Src family kinases that renders FAK phosphorylated at several other sites and leads to enhanced FAK activation [ 12, 13].

This work establishes that the initial activation by phenylalanine involves binding at a site other than the active site.

The results of the experiments described here strongly support a model in which activation of PheH by phenylalanine involves binding at a site other than the active site.

The observation of this fluorescence change in a mutant protein unable to bind phenylalanine in the active site establishes that a protein conformational change consistent with activation involves binding at a site other than the active site.

Based on the fact that only 17% of total BRG1 is contained in GBAF complexes (Fig. 2b), we cannot rule out esBAF and PBAF binding at these sites or other compensatory mechanisms.

Interaction of LTA at other binding sites yielded irrelevant FlexX score.

An initial binding event at one site pre-organizes other sites, thereby reducing their degrees of freedom, which reduces the entropic costs of their interaction (7).