Sentence examples for binding at nanomolar concentrations from inspiring English sources

Bortezomib (Velcade® PS-341, 20), a proteasome inhibitor, inhibits p300-HIF-1 α binding at nanomolar concentrations.

Proteasome-shuttling factors, such as the Rad23 proteins, not only bind K48-polyUb conjugates but also, at nanomolar concentrations, stimulate Ub conjugate binding to the proteasome (Nathan et al., 2013).

To overcome this, we exploited the weak binding dynein mutant that does not bind appreciably to the microtubule even at nanomolar concentrations.

In this work we show that the polysulfonated napthylurea suramin is capable of binding to falcipain-2, inhibiting its catalytic activity at nanomolar concentrations against both synthetic substrates and the natural substrate hemoglobin.

The binding is specific to the extent that fibrinogen at nanomolar concentrations bound to immobilized native collagen, but not denatured collagen.

NBI-31772 inhibited the binding of I-labeled IGF-1 to IGFBP-3 at nanomolar concentrations.

The most promising compound in this series was 2- 3′,4′,5′-trimethoxybenzoyl -3-methyl-6-ethoxy-benzo[b]furan, which inhibits cancer cell growth at nanomolar concentrations and interacts strongly with tubulin by binding to the colchicine site.

The existence of sharply defined current levels and the exponential distribution of arrival times between signal spikes at nanomolar concentrations suggest a Poisson process in which the individual binding events are being resolved.

C-peptide even at very low concentration abolished these effects, consistent with its activity at nanomolar concentrations found in plasma [ 43] and full saturation of C-peptide binding sites at low nanomolar concentrations [ 38].

The maximum antagonistic effect was observed at nanomolar concentrations (1 × 10-10 to 1 × 10-8 M).

Some derivatives proved to be highly effective in inhibiting HIV-1 replication at nanomolar concentrations.