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The antibody was well tolerated up to weekly doses of 10 mg/kg, and had a dose-dependent half-life ranging from 0.19 to 11.81 days over the doses 0.1 10 mg/kg, indicating tissue binding at low doses [ 66].
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Because the tissue-binding capacity is limited at low doses already, tissue accumulation of linagliptin does not occur after multiple oral administration.
Thus therapies which target one or a subset of duplicate genes may not be effective, at low doses due to binding affinities to variable targets.
Thus, high-dose experiments cannot be used to predict low-dose results mediated by EDCs binding to hormone receptors and altering receptor-mediated responses at low doses.
Using X-ray (115 kVp) at low doses (<50 cGy or Rad), specific and irreversible binding was found on striatal dopamine transporters with 3 photoaffinity ligands for dopamine transporters, to different extents.
And we know that at low doses the risks are low.
Tests showed that some chemicals had no noticeable effect at low doses, but when mixed with others at similarly low doses, the cocktail was harmful to sperm.
Although it's an anaesthetic, at low doses it raises heart rate.
For doctors, that means starting medications at low doses and increasing them gradually.
At low doses, most experts say, most of these natural remedies are probably safe.
Minor direct toxicities at low doses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com